FDA-approved safety with comprehensive monitoring every step of the way

Safety is our top priority. With almost 20,000 treatments administered at our New Jersey centers, we have extensive experience managing Spravato's well-documented side effects and ensuring every patient receives the safest possible care.

What to Expect: Common Side Effects and How We Manage Them

Let's be completely transparent about what you might experience during and after Spravato treatment. Most side effects are mild to moderate, predictable, and resolve within 2 hours. Our experienced team knows exactly how to help you through any discomfort, and we monitor you continuously to ensure your safety.

Here is the list of the 5 Most Common Spravato Side Effects (and what we do about them).

- Experienced by about 75% of patients
- Usually peaks 15-40 minutes after treatment and fades within 90 minutes
- We provide a comfortable, quiet environment and reassuring presence
- Many patients find this effect manageable and even relaxing once they know what to expect

- Experienced by about 35% of patients
- We help you move slowly and provide assistance getting up
- Comfortable seating and hydration minimize this effect
- Always resolves before you're cleared to leave

 - Experienced by about 25% of patients
- We recommend eating a light meal 1-2 hours before treatment (not immediately before)
- Anti-nausea medication is available if needed
- Nausea is typically mild and short-lived

- We check your blood pressure before, during, and after treatment
- Usually returns to baseline within 2 hours
- Temporary increase is expected and we are comfortable medically managing it

- Some patients feel tired after treatment
- Plan for rest after your session
- This often improves as your body adjusts to treatment
- Many patients actually report increased energy as depression improves

Our Comprehensive Safety Monitoring Protocol

Every Spravato treatment at our New Jersey centers follows strict FDA-mandated safety protocols. You're never alone during treatment, and our trained medical team continuously monitors your vital signs and overall wellbeing throughout the entire process.

Before Each Treatment:
  • Complete health assessment and vital signs check
  • Blood pressure and heart rate monitoring
  • Review of any changes in medications or health status
  • Discussion of any concerns from previous treatments
During Treatment (Continuous 2-Hour Supervision):
  • Vital signs monitored at set intervals
  • Licensed medical staff present at all times
  • Comfortable, safe environment designed for relaxation
  • Immediate access to emergency protocols if needed
  • Side effect assessment and management in real-time
Before You Leave:
  • Final vital signs check to ensure stability
  • Assessment of dissociation and cognitive function
  • Confirmation that you're safe to travel home
  • Arranged transportation (driving not permitted for remainder of day)
  • Clear instructions for post-treatment care

What Makes Our Centers Different:

With over 10,000 Spravato treatments administered, our staff has seen and successfully managed every possible side effect scenario. Our medical team includes clinicians trained specifically in esketamine administration and monitoring. We maintain emergency protocols and have direct relationships with local emergency services, though serious adverse events are extremely rare and we have never had to activate them!

24/7 Support:

Our depression specialists are available around the clock if you have any concerns between treatments. We provide every patient with direct contact information and encourage you to reach out with any questions about side effects or your treatment experience.

Ready to Experience Safe, Expert-Monitored Treatment?

Now that you understand what to expect, take the next step toward breakthrough depression relief. Our experienced medical team has safely guided thousands of patients through Spravato treatment with comprehensive monitoring and expert side effect management.

Our REMS-certified specialists will verify your insurance coverage, assess your eligibility for Spravato treatment, and answer any questions about the process. Most screenings are completed within 24 hours, with same-day appointments available for qualified candidates. 

  • Rapid relief - often within hours, not weeks
  • FDA-approved and proven effective
  • Most insurance plans accepted
  • Nearly 20,000 treatments administered
  • REMS-certified treatment specialists
  • Same-day appointments available
  • 24/7 access to our depression specialists
  • 97%+ insurance approval rate
  • Comfortable, spa-like treatment environment
  • Comprehensive mental health care
  • No lengthy waiting lists for urgent cases
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    *Insurance information is optional. Include if you'd like us to check your benefits before we call you.

    FDA Clinical Trial Data: Proven Safety Across Thousands of Patients

    /01

    Clinical Trial Safety Results

    Over 20,000 patients studied across multiple Phase 2 and Phase 3 trials
    No serious safety signals identified in controlled studies
    Well-tolerated profile with predictable, manageable side effects
    Extensive long-term data showing sustained safety over years of treatment
    /03

    Post-Market Surveillance

    Since FDA approval in 2019, over 100,000 patients worldwide have received Spravato treatment with continued safety monitoring. Real-world data consistently confirms the clinical trial findings, with no new safety concerns identified.
    /05

    Comparison to Traditional Antidepressants

    Unlike some traditional antidepressants that can cause weight gain, sexual dysfunction, or withdrawal symptoms, Spravato's side effects are typically short-term and resolve within hours. There's no risk of physical dependence, and patients can discontinue treatment without withdrawal symptoms.
    /02

    FDA Breakthrough Therapy Designation

    Spravato received special FDA Breakthrough Therapy status, reserved for treatments that demonstrate substantial improvement over existing options while maintaining acceptable safety profiles. This designation expedited the review process because the FDA recognized both the urgent need and the compelling safety data.
    /04

    REMS Program Excellence

    The FDA's Risk Evaluation and Mitigation Strategy (REMS) isn't a warning—it's a gold standard safety framework that ensures every treatment center meets the highest possible standards. This program demonstrates the FDA's confidence in Spravato's safety when administered properly by trained professionals.
    /06

    Bottom Line on Safety

    Spravato's safety profile isn't based on theory—it's backed by extensive clinical trials involving over 20,000 patients across multiple years of rigorous study. Before receiving FDA approval in 2019, esketamine underwent some of the most comprehensive safety testing in psychiatric medication history.

    Who Should Not Receive Spravato: Important Safety Considerations

    While Spravato is safe for most patients with treatment-resistant depression, certain medical conditions require special consideration or may prevent treatment. During your consultation, our medical team thoroughly reviews your health history to ensure Spravato is both safe and appropriate for you.

    Medication Interactions:
    We carefully review all your current medications, supplements, and over-the-counter drugs. Some medications may need timing adjustments, while others might require temporary discontinuation.

    Our Comprehensive Screening Process:
    Every patient receives a thorough medical evaluation including detailed history, physical examination, and review of recent lab work or cardiac studies when indicated. We never rush this process—your safety depends on getting it right from the start.



    Absolute Contraindications (Cannot Receive Spravato):
    ■ Aneurysmal vascular disease or arteriovenous malformation
    ■ History of intracerebral hemorrhage (bleeding in the brain)
    ■ Hypersensitivity to esketamine, ketamine, or any component of the formulation

    Conditions Requiring Special Caution:
    ■ Uncontrolled high blood pressure (we may need to stabilize this first)
    ■ Recent heart attack or unstable heart disease (timing and cardiac clearance important)
    ■ Moderate to severe liver impairment (may affect medication processing)
    ■ Active substance abuse (particularly alcohol or drugs affecting the central nervous system)
    ■ Psychotic disorders like schizophrenia (may worsen certain symptoms)

    Pregnancy and Breastfeeding:
    Spravato should be avoided during pregnancy and breastfeeding to avoid infant exposure.

    Age Considerations:
    ■ Adults 18-64: Standard dosing and monitoring
    ■ Adults 65+: Extra monitoring for blood pressure and cognitive effects
    ■ Under 18: Not currently FDA-approved for pediatric use

    Your Breakthrough Moment is Waiting

    When traditional treatments haven't brought relief, hope can feel distant. Our experienced team has helped nearly 20,000 patients find breakthrough relief with Spravato.

    Your journey to feeling like yourself again starts with one conversation. Call today - most insurance plans accepted.

    (908) 450 7002
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